Biotechnology Fermentation Factory | NIZO (2025)

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The Biotechnology Fermentation Factory (BFF) in Ede is a state-of-the-art, open-access scale-up facility dedicated to advancing production of foods and food ingredients through fermentation technology, including precision fermentation. Operated though NIZO Food Research, the BFF is designed to help companies scale their innovations from concept to commercialization, enabling a more sustainable and diverse food future.

What Does the BFF Offer?

• Food-Grade (Precision) Fermentation Facility:
  The BFF provides cutting-edge infrastructure for scaling up aerobic fermentation processes up to 10,000L in a food-grade environment, ensuring safety, quality, and regulatory compliance, including materials containing genetically modified microorganisms, such as yeast, fungi, and bacteria:
  – Precision fermentation
  – Microbial biomass
  – Side stream valorisation (liquid) through fermentation
• Cost-Effective Scaling:
  From laboratory to pilot scale; the BFF eliminates the need for start-ups and growing companies to invest in expensive infrastructure, accelerating innovation and reducing time-to-market.
• Seamless Integration with NIZO’s Food and Health Expertise:
  Located on NIZO’s campus, the facility connects directly to NIZO’s extensive food-grade downstream processing (DSP) pilot plant, food application center and laboratories. This enables end-to-end support for analytics, process optimization, product development, and application research.
• Access to NIZO’s Comprehensive Services and Contract Research:
  – Analytical and regulatory support
  – Process and product development
  – Commercialization guidance
  – Access to NIZO’s vast expertise in: strain development, fermentation, product development and analytics, taste and texture, food safety and shelf life, digestion and nutritional value, process development and food-grade scaling.

Who Can Benefit from the BFF?

The BFF is designed for companies and researchers working in:

• Precision fermentation
• Alternative proteins
• Microbial biomass
• Food ingredient production using microbes
• Sustainable and innovative food technologies

Whether you’re a start-up, scale-up, established player or research organization, the BFF provides the tools and expertise you need to succeed.

Why Choose the BFF?

• Access to NIZO’s 75+ years of experience and professional support in your food innovation
• Support from a collaborative ecosystem in the Netherlands
• Collaborative mindset; with you and your partners. Together we can achieve more.
• A commitment to sustainability, health, and innovation

BFF kick-off event

To celebrate the launch and introduce the BFF to our partners, customers, investors and ecosystem members, we are hosting an event. This will be a unique opportunity to:

• Discover how the BFF can accelerate food innovation
• Take an exclusive look into the 3D-model of the BFF and get your questions answered
• Take a tour trough the NIZO pilot plant and R&D innovations
• Connect with key players in fermentation, food tech, and investment
• Explore collaboration opportunities in this pioneering facility

When & Where?

When: June 6, 2025
Location: NIZO & BFF, Kernhemseweg 2, Ede, The Netherlands
Time: 11-17

Agenda & Registration

Contact Us

Ready to learn more or discuss your project needs? Please contact us:

• Email: info@bff-ede.com
• Phone: +31 318 659511

Partners

The Biotechnology Fermentation Factory (BFF) is made possible through the collaboration and support of our valued partners, including:

• NIZO Food Research
• The Cellular Agriculture Netherlands Foundation (CAN)
• The Dutch government’s National Growth Fund (NGF)
• OostNL and Perspectieffonds Gelderland
• Cultivate at Scale (CaS)

Join us at the Biotechnology Fermentation Factory and become part of the movement transforming food systems worldwide!

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